潘惠麟导师主页
基本信息
姓名: 潘惠麟
性别:
最高学历(学位): 博士研究生
专业技术职务: 教授
行政职务: 科长
学科所在单位: 生物科学技术学院
电子邮箱: huilinpan@mdanderson.org
学术头衔:
学术兼职: 美国心血管委员会理事,美国疼痛管理委员会理事
研究方向: 分子遗传学
学科信息
导师类别招生学院招生专业
兼职学术学位博士生导师 生物科学技术学院 遗传学
个人简介
学术研究方向、重要创新成果及其科学价值或社会经济意义: 1、炎症疼痛的机制以及消炎止疼药物筛选。候选人团队通过建立动物模型,为认识神经病理性疼痛的机制以及筛选治疗性药物提供了有力的工具。神经痛在临床上的治疗药物效果有限且有明显的副作用。本团队致力于系统研究神经损伤引起的慢性神经痛的分子机制,包括电压门控和受体门控的离子通道,G蛋白受体等膜蛋白、受体在神经系统中的信息传递机制。研究成果不仅提高了对慢性神经痛发生的分子机制的认识,而且为该疾病的治疗提供了新的研究思路。 2、表观遗传研究。候选人带领的研究团队还从表观遗传方向入手研究慢性神经痛的DNA甲基化、组蛋白修饰的变化,发现重要的修饰位点,同时筛选到相应的作用于该位点的药物,为慢性神经痛的机制研究开辟了新的方向,为疼痛管理的治疗介入提供了新靶标、新药物。 3、下丘脑的高血压神经,细胞分子机制的研究。候选人带领的研究团队及其合作者的主要研究方向之一是高血压的神经发病机制。高血压是临床上的常见病多发病,并且是其他心血管疾病如心衰,脑卒中,肾衰的诱因。 在近五年的研究中,首次发现兴奋性氨基酸谷氨酸代谢型受体mGluR5在高血压大鼠下丘脑神经元上的表达及活性是升高的。并且此受体活性的升高在维持高血压大鼠高交感神经状态中起重要作用。 抑制mGluR5受体的活性可降低下丘脑中支配交感神经活动的特定神经元放电活动降低,并能够降低血压和交感神经张力。后续研究还发现调控兴奋性氨基酸受体的一些激酶和信号转导系统在高血压大鼠神经元上的可塑性变化。比如: 高血压大鼠下丘脑神经元中小电导型钙依赖性钾通道活动的降低以及和钙通透性AMPA受体的表达和活性的变化。这些研究发现为治疗高血压寻找新的靶点提供了理论依据。 4、慢性应激状态下下丘脑神经中枢的细胞分子机制。 候选人研究团队获得了美国健康研究院精神健康研究院(NIMH)五年的资助,研究慢性应激状态下下丘脑神经中枢的细胞分子机制。我们将会应用在体和离体电生理学,转基因, 药理学, 等种实验技术对慢性应激导致的下丘脑中的神经可塑性变化进行系统研究。该研究会对防治和治疗慢性应激相关的抑郁症有重要指导意义。 5、肥胖的下丘脑的饮食调节功能。 该研究会对防治和治疗糖尿病和肥胖有重要指导意义。 LIST OF PEER‐REVIEWED GRANT AWARDS — COMPLETED 1. Stimulation of Cardiac Nociceptors during Ischemia. Bowman Gray School of Medicine Venture Grant; 01/1997‐12/1997 — Principal Investigator. 2. Sensory Mechanisms of Visceral Pain. Center for Investigative Neuroscience/Bowman Gray School of Medicine; 07/1997‐06/1998 — Principal Investigator. 3. Role of Bradykinin in Cardiac Afferent Stimulation during Ischemia. American Heart Association, Mid‐Atlantic Affiliate (#GS‐30); 07/1997‐12/1999 — Principal Investigator. 4. Instrumentation for Confocal Imaging and Analysis. NIH/National Center for Research Resources (S10 RR16861); 04/2002‐03/2003 — Co‐Investigator (PI: B. Stanley). 5. Spinal Plasticity in Diabetic Neuropathic Pain. NIH/National Institute of Neurological Disorders and Stroke (R21 NS41178); 10/2000‐09/2003 — Principal Investigator. 6. Integrative Control of Cardiovascular Function. NIH/National Heart, Lung, and Blood Institute (K02 HL04199); 05/2000‐04/2005 — Principal Investigator (early termination in December 2004 due to multiple concurrent NIH R01 awards). 7. Synaptic Mechanisms Regulating Spinally Projecting Paraventricular Neurons. Postdoctoral Fellowship Award (PI: De‐Pei Li), American Heart Association, Pennsylvania/Delaware Affiliate; 07/2002‐06/2004 — Mentor. 8. Mechanisms of Opioid Action in the Amygdala. Predoctoral Fellowship, NIH/National Institute on Drug Abuse (F31 DA18001); 02/2004‐01/2006 (PI: Thomas F. Finnegan) — Thesis Advisor & Mentor. 9. Paraventricular Nucleus and the Autonomic Control. Predoctoral Fellowship, American Heart Association, Pennsylvania/Delaware Affiliate; 07/2004‐06/2006 (PI: Matthew R. Zahner) — Thesis Advisor & Mentor. 10. Mechanisms of Activation of Cardiac Nociceptors. NIH/National Heart, Lung, and Blood Institute (R01 HL60026); 04/1998‐03/2007 — Principal Investigator. 11. Signaling Mechanisms of Activation of Cardiac Nociceptors by Bradykinin. Postdoctoral Fellowship, American Heart Association, Texas Affiliate; 07/2007‐06/2009 (PI: Zi‐Zhen Wu) — Mentor. 12. Hypothalamic GABAergic Plasticity in Hypertension. Postdoctoral Fellowship, American Heart Association, South Central Affiliate; 07/2010‐06/2012 (PI: Zeng‐You Ye) — Mentor. 13. Hypothalamic GABAergic Action and Energy Homeostasis. NIH/National Institute of Diabetes and Digestive and Kidney Diseases (R56 DK089426); 10/2010‐09/2012 — Co‐Investigator (PI: Qingchun Tong). 14. Mechanisms of Neural Plasticity in Neuropathic Pain. NIH/National Institute of General Medical Sciences (R01 GM064830); 04/2001‐06/2012 — Principal Investigator. 15. Mechanisms Underlying Glucose‐Lowering Effects of Leptin in Type 1 Diabetes. Juvenile Diabetes Research Foundation; 07/2010‐09/2013 — Co‐Investigator (PI: Qingchun Tong). 16. Neuron‐Specific Block of T‐type Calcium Channels. NIH/National Institute of Neurological Disorders and Stroke (R21 NS069524); 08/2011‐07/2013 — Co‐Investigator (PI: Edward Perez‐ Reyes). 17. Mechanisms of Spinal Plasticity in Diabetic Neuropathic Pain. NIH/National Institute of Neurological Disorders and Stroke (R01 NS045602); 10/2003‐09/2013 — Principal Investigator. 18. Sim1 Neurons and Body Weight Regulation. NIH/National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK092605); 04/2012‐03/2016 — Co‐Investigator (PI: Qingchun Tong). 19. Synaptic Mechanisms Regulating Sympathetic Drive. NIH/National Heart, Lung, and Blood Institute (R01 HL077400); 06/2005‐05/2016 — Principal Investigator. 20. Neuronal Plasticity and Signaling in Neuropathic Pain. NIH/National Institute of Neurological Disorders and Stroke (R01 NS073935); 03/2011‐07/2016 — Principal Investigator. LIST OF NIH GRANT AWARDS — ACTIVE 1. Mechanisms of CNS Neuronal Plasticity in Hypertension. NIH/National Heart, Lung, and Blood Institute (R01 HL131161); 04/2016‐03/2020 — Principal Investigator. Direct cost: $327,007/year. 2. Epigenetic Mechanisms of Neuropathic Pain. NIH Blueprint for Neuroscience Research – Grand Challenge on Chronic Pain (R01 DE022015); 08/2011‐07/2017 — Principal Investigator (Co‐PI: Jean‐ Pierre Issa). Direct cost: $450,000/year. 3. Mechanisms of Neuronal Plasticity in Neuropathic Pain. NIH/National Institute of General Medical Sciences (R01 GM120844); 08/2016‐07/2020 — Principal Investigator. Direct cost: $255,062/year. LIST OF NIH GRANT APPLICATIONS — PENDING 1. Signaling Mechanisms of Opioid‐Induced Hyperalgesia and Tolerance. NIH/National Institute on Drug Abuse (R01 DA041711); 12/2016‐11/2021 — Principal Investigator. Direct cost: $328,000/year. 2. Molecular Determinants of Synaptic Plasticity in Neuropathic Pain. NIH/National Institute of Neurological Disorders and Stroke (R01 NS10188); 04/2017‐03/2022 — Principal Investigator (Co‐PI: Shao‐Rui Chen). Direct cost: $328,000/year. ACADEMIC AWARDS AND HONORS 06/1988: Outstanding Graduate Student Thesis Award, Tongji Medical University. 07/1993‐06/1995: Postdoctoral Research Fellowship Award, American Heart Association, California Affiliate. 07/1995‐06/1996: Postdoctoral Research Fellowship Award (renewed with competitive review), American Heart Association, California Affiliate. 05/2000‐04/2005: Independent Scientist Career Award, National Heart, Lung, and Blood Institute, National Institutes of Health. 07/2003: Early Promotion and Tenure Award, Pennsylvania State University. 07/2003‐02/2006: Julien F. Biebuyck Endowed Professorship in Anesthesiology, Pennsylvania State University College of Medicine. 02/2006‐present: Helen T. Hawkins Distinguished Professorship in Cancer Research, The University of Texas MD Anderson Cancer Center. 10/2009: Distinguished Mentor Award, Postdoctoral Association, University of Texas MD Anderson Cancer Center.